Apo-Brimonidide may be available in the countries listed below.
Brimonidine tartrate (a derivative of Brimonidine) is reported as an ingredient of Apo-Brimonidide in the following countries:
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Genoclom may be available in the countries listed below.
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Cosaar may be available in the countries listed below.
Losartan potassium salt (a derivative of Losartan) is reported as an ingredient of Cosaar in the following countries:
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Azitromycine Teva may be available in the countries listed below.
Azithromycin is reported as an ingredient of Azitromycine Teva in the following countries:
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Clevian may be available in the countries listed below.
Piroxicam is reported as an ingredient of Clevian in the following countries:
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Belfix-CV may be available in the countries listed below.
Cefixime is reported as an ingredient of Belfix-CV in the following countries:
Clavulanic Acid potassium (a derivative of Clavulanic Acid) is reported as an ingredient of Belfix-CV in the following countries:
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Lamotrigin Valeant may be available in the countries listed below.
Lamotrigine is reported as an ingredient of Lamotrigin Valeant in the following countries:
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Piperacillin Fresenius may be available in the countries listed below.
Piperacillin sodium salt (a derivative of Piperacillin) is reported as an ingredient of Piperacillin Fresenius in the following countries:
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In the US, Glucotrol (glipizide systemic) is a member of the drug class sulfonylureas and is used to treat Diabetes, Type 2.
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Glipizide is reported as an ingredient of Glucotrol in the following countries:
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Cinnarizin Biomeda may be available in the countries listed below.
Cinnarizine is reported as an ingredient of Cinnarizin Biomeda in the following countries:
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Flutide Evohaler may be available in the countries listed below.
Fluticasone propionate (a derivative of Fluticasone) is reported as an ingredient of Flutide Evohaler in the following countries:
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Colchicine Mylan may be available in the countries listed below.
Colchicine is reported as an ingredient of Colchicine Mylan in the following countries:
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Triflux may be available in the countries listed below.
Triflusal is reported as an ingredient of Triflux in the following countries:
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Euphylline L.A. may be available in the countries listed below.
Theophylline is reported as an ingredient of Euphylline L.A. in the following countries:
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Ambroxol-CT may be available in the countries listed below.
Ambroxol hydrochloride (a derivative of Ambroxol) is reported as an ingredient of Ambroxol-CT in the following countries:
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Theracough may be available in the countries listed below.
Guaifenesin is reported as an ingredient of Theracough in the following countries:
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Papaverin Recip may be available in the countries listed below.
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Telebrix Gastro may be available in the countries listed below.
Ioxitalamic Acid meglumine (a derivative of Ioxitalamic Acid) is reported as an ingredient of Telebrix Gastro in the following countries:
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Maledrol may be available in the countries listed below.
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Lindoxyl may be available in the countries listed below.
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Almagel may be available in the countries listed below.
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Risperidone-Arrow 1 may be available in the countries listed below.
Risperidone is reported as an ingredient of Risperidone-Arrow 1 in the following countries:
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Losartan Davur may be available in the countries listed below.
Losartan potassium salt (a derivative of Losartan) is reported as an ingredient of Losartan Davur in the following countries:
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Glucofor may be available in the countries listed below.
Metformin hydrochloride (a derivative of Metformin) is reported as an ingredient of Glucofor in the following countries:
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In the US, Tyvaso (treprostinil systemic) is a member of the drug class agents for pulmonary hypertension and is used to treat Pulmonary Arterial Hypertension.
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Neomycin sulfate (a derivative of Neomycin) is reported as an ingredient of Biosol in the following countries:
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Progynova Parches may be available in the countries listed below.
Estradiol is reported as an ingredient of Progynova Parches in the following countries:
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Acide arsanilique may be available in the countries listed below.
Acide arsanilique (DCF) is also known as Arsanilic Acid (Rec.INN)
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Glossary
| DCF | Dénomination Commune Française |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
Ampivet may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Ampicillin is reported as an ingredient of Ampivet in the following countries:
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Infectomox may be available in the countries listed below.
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Cerivin may be available in the countries listed below.
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Tamoxifen Nordic Drugs may be available in the countries listed below.
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Betanol may be available in the countries listed below.
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Xanor may be available in the countries listed below.
Alprazolam is reported as an ingredient of Xanor in the following countries:
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Utovlan.
Each tablet contains 5mg norethisterone Ph Eur.
For excipients see Section 6.1.
White, flat, circular, bevel-edged tablet inscribed 'SEARLE' on one side and 'U' on the other.
At low dose: Dysfunctional uterine bleeding, endometriosis, polymenorrhoea, menorrhagia, metropathia, haemorrhagia, postponement of menstruation and premenstrual syndrome.
At high dose: Disseminated carcinoma of the breast.
Oral Administration
Low dose
Dysfunctional uterine bleeding, polymenorrhoea, menorrhagia, dysmenorrhoea and metropathia haemorrhagia: 1 tablet three times daily for 10 days; bleeding usually stops within 48 hours. Withdrawal bleeding resembling true menstruation occurs a few days after the end of treatment. One tablet twice daily, from days 19 to 26 of the two subsequent cycles, should be given to prevent recurrence of the condition.
Endometriosis: 1 tablet three times daily for a minimum treatment period of six months. The dosage should be increased to 4 or 5 tablets a day if spotting occurs. The initial dosage should be resumed when bleeding or spotting stops.
Postponement of menstruation: 1 tablet three times daily, starting three days before the expected onset of menstruation. Menstruation usually follows within three days of finishing the treatment.
Pre-menstrual syndrome: 1 tablet daily from days 16 to 25 of the menstrual cycle.
High dose
For disseminated breast carcinoma the starting dose is 8 tablets (40mg) per day increasing to 12 tablets (60mg) if no regression is noted.
Pregnancy
Previous idiopathic or current venous thromboembolism (deep vein thrombosis, pulmonary embolism)
Active or recent arterial thromboembolic disease (e.g. angina, myocardial infarction)
Disturbance of liver function
History during pregnancy of idiopathic jaundice
Severe pruritus or pemphigoid gestationis
Undiagnosed irregular vaginal bleeding
Porphyria
Known hypersensitivity to norethisterone or any of the excipients
If menstrual bleeding should fail to follow a course of Utovlan, the possibility of pregnancy must be excluded before a further course is given.
Therapy should be discontinued if the following occur:
- Jaundice or deterioration in liver function
- Significant increase in blood pressure
- New onset of migraine-type headache
Progestogens may cause fluid retention. Special care should be taken when prescribing norethisterone in patients with conditions which might be aggravated by this factor:
- Epilepsy
- Migraine
- Asthma
- Cardiac dysfunction
- Renal dysfunction
Risk of venous thromboembolism (VTE)
Long term use of low dose progestogens as part of combined oral contraception or combined hormone replacement therapy has been associated with an increased risk of venous thromboembolism, although the role of progestogens in this aetiology is uncertain. A patient who develops symptoms suggestive of thromboembolic complications should have her status and need for treatment carefully assessed before continuing therapy.
Any patient who develops an acute impairment of vision, proptosis, diplopia or migraine headache should be carefully evaluated ophthalmologically to exclude papilloedema or retinal vascular lesions before continuing medication.
Generally recognised risk factors for VTE include a personal history or family history, severe obesity (BMI >30 kg/m2) and systemic lupus erythematosus (SLE). There is no consensus about the possible role of varicose veins in VTE.
Treatment with steroid hormones may add to these risk factors. Personal or strong family history of thromboembolism or recurrent spontaneous abortion should be investigated in order to exclude a thrombophillic predisposition. Until a thorough evaluation of thrombophillic factors has been made or anticoagulant treatment initiated, use of progestogens in these patients should be viewed as contraindicated. Where a patient is already taking anticoagulants, the risks and benefits of progestogen therapy should be carefully considered.
The risk of VTE may be temporarily increased with prolonged immobilisation, major trauma or major surgery. As in all post-operative patients, scrupulous attention should be given to prophylactic measures to prevent VTE. Where prolonged immobilisation is likely to follow elective surgery, particularly abdominal or orthopaedic surgery to the lower limbs, consideration should be given to stopping progestogen therapy 4-6 weeks pre-operatively. Treatment should not be restarted until the patient is fully remobilised.
If VTE develops after initiating therapy the drug should be withdrawn. Patients should be advised to contact their doctor immediately if they become aware of a potential thromboembolic symptom (e.g., painful swelling in the leg, sudden pain in the chest, dyspnoea).
Interaction with other medicines
The metabolism of progestogens may be increased by concommitant administration of compounds known to induce drug-metabolising enzymes, specifically cytochrome P450 enzymes. These compopunds include anticonvulsants (e.g., phenobarbital, phenytoin, carbamezapin) and anti-infectives (e.g., rifampicin, rifabutin, nevirapine, efavirenz, tetracyclines, ampicillin, oxacillin and cotrimoxazole)
Ritonavir and nelfinavir, although known as strong inhibitors, by contrast exhibit inducing properties when used concomitantly with steroid hormones. Herbal preparations containing St John's Wort (Hypericum Perforatum) may induce the metabolism of progestogens. Progestogen levels may therefore be reduced.
Aminoglutethimide has been reported to decrease plasma levels of some progestogens.
Concurrent administration of cyclosporin and norethisterone has been reported to lead to increased plasma cyclosporin levels and/or decreased plamsa norethisterone levels.
When used in combination with cytotoxic drugs, it is possible that progestogens may reduce the haematological toxicity of chemotherapy.
Special care should be taken when progestogens are administered with other drugs which also cause fluid retention, such as NSAIDs and vasodilators.
Other forms of interaction
Progestogens can influence certain laboratory tests (e.g., tests for hepatic function, thyroid function and coagulation).
Contra-indicated in pregnancy.
None.
Progestogens given alone at low doses have been associated with the following undesirable effects:
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Overdosage may be manifested by nausea, vomiting, breast enlargement and later vaginal bleeding. There is no specific antidote and treatment should be symptomatic.
Gastric lavage may be employed if the overdosage is large and the patient is seen sufficiently early (within four hours).
Pharmotherapeutic group (ATC code) L02A B.
Norethisterone given at intermediate doses (5-10mg) suppresses ovulation via its effect on the pituitary. The endogenous production of oestrogens and progesterones are also suppressed, and the ectopic endometrium is converted to a decidua resembling that of pregnancy. In carcinoma norethisterone may act by pituitary inhibition or by direct action on tumour deposits.
Norethisterone is rapidly and completely absorbed after oral administration, peak plasma concentration occurring in the majority of subjects between 1 and 3 hours. Due to first-pass metabolism, blood levels after oral administration are 60% of those after i.v. administration. The half life of elimination varies from 5 to 12 hours, with a mean of 7.6 hours. Norethisterone is metabolised mainly in the liver. Approximately 60% of the administered dose is excreted as metabolites in urine and faeces.
The toxicity of norethisterone is very low. Reports of teratogenic effects in animals are uncommon. No carcinogenic effects have been found even in long-term studies.
maize starch
polyvidone
magnesium stearate
lactose
None stated.
The shelf life of Utovlan tablets is 3 years.
Store in a dry place, below 25oC, away from direct sunlight.
Utovlan tablets are supplied in pvc/foil blister packs of 30 and 90 tablets.
None.
Pharmacia Limited
Ransgate Road
Sandwich
Kent CT13 9NJ, UK
PL 00032/0423
15th July 2002/15th February 2003
May 2007
Company Ref: UT 2_0
Tradorec may be available in the countries listed below.
UK matches:
Tramadol hydrochloride (a derivative of Tramadol) is reported as an ingredient of Tradorec in the following countries:
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Glossary
| SPC | Summary of Product Characteristics (UK) |
Lopresor SR may be available in the countries listed below.
Metoprolol tartrate (a derivative of Metoprolol) is reported as an ingredient of Lopresor SR in the following countries:
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Permoxin may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Permethrin is reported as an ingredient of Permoxin in the following countries:
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In the US, Ethrane is a member of the drug class general anesthetics.
Enflurane is reported as an ingredient of Ethrane in the following countries:
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Thia-1 may be available in the countries listed below.
Thiamine hydrochloride (a derivative of Thiamine) is reported as an ingredient of Thia-1 in the following countries:
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Pharex Norfloxacin may be available in the countries listed below.
Norfloxacin is reported as an ingredient of Pharex Norfloxacin in the following countries:
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In the US, Enbrel (etanercept systemic) is a member of the following drug classes: antirheumatics, TNF alfa inhibitors and is used to treat Ankylosing Spondylitis, Behcet's Disease, Bullous Pemphigoid, Cogan's Syndrome, Histiocytosis, Juvenile Idiopathic Arthritis, Juvenile Rheumatoid Arthritis, Macrophage Activation Syndrome, Pemphigoid, Pemphigus, Psoriasis, Psoriatic Arthritis, Rheumatoid Arthritis, SAPHO Syndrome, Still's Disease, Uveitis and Wegener's Granulomatosus.
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UK matches:
Etanercept is reported as an ingredient of Enbrel in the following countries:
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Glossary
| SPC | Summary of Product Characteristics (UK) |
Cacit Vitamine D3 may be available in the countries listed below.
Calcium Carbonate is reported as an ingredient of Cacit Vitamine D3 in the following countries:
Colecalciferol is reported as an ingredient of Cacit Vitamine D3 in the following countries:
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Afisolone may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Prednisolone is reported as an ingredient of Afisolone in the following countries:
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Codotussyl Expectorant Acétylcystéine may be available in the countries listed below.
Acetylcysteine is reported as an ingredient of Codotussyl Expectorant Acétylcystéine in the following countries:
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Acido Alendronico Farmoz may be available in the countries listed below.
Alendronic Acid is reported as an ingredient of Acido Alendronico Farmoz in the following countries:
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Azithromycine Monodose Sandoz may be available in the countries listed below.
Azithromycin monohydrate (a derivative of Azithromycin) is reported as an ingredient of Azithromycine Monodose Sandoz in the following countries:
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Lopéramide ratiopharm Conseil may be available in the countries listed below.
Loperamide hydrochloride (a derivative of Loperamide) is reported as an ingredient of Lopéramide ratiopharm Conseil in the following countries:
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Panacetamol may be available in the countries listed below.
Paracetamol is reported as an ingredient of Panacetamol in the following countries:
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Apo-Gain may be available in the countries listed below.
Minoxidil is reported as an ingredient of Apo-Gain in the following countries:
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In the US, Habitrol (nicotine systemic) is a member of the drug class smoking cessation agents and is used to treat Smoking Cessation.
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L-Methionine may be available in the countries listed below.
L-Methionine (JAN) is known as Methionine in the US.
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Glossary
| JAN | Japanese Accepted Name |
Rec.INN
N05BA10
0027223-35-4
C20-H17-Cl-N2-O3
368
Anxiolytic agent
Benzodiazepine derivative
4H-[1,3]Oxazino[3,2-d][1,4]benzodiazepine-4,7(6H)-dione, 11-chloro-8,12b-dihydro-2,8-dimethyl-12b-phenyl-
International Drug Name Search
Glossary
| BAN | British Approved Name |
| DCF | Dénomination Commune Française |
| DCIT | Denominazione Comune Italiana |
| IS | Inofficial Synonym |
| OS | Official Synonym |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
| USAN | United States Adopted Name |
Pannox may be available in the countries listed below.
Cloxacillin sodium salt (a derivative of Cloxacillin) is reported as an ingredient of Pannox in the following countries:
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Apifrin-Z may be available in the countries listed below.
Phenylephrine hydrochloride (a derivative of Phenylephrine) is reported as an ingredient of Apifrin-Z in the following countries:
Zinc Sulfate is reported as an ingredient of Apifrin-Z in the following countries:
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Pregvomit may be available in the countries listed below.
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Mesol may be available in the countries listed below.
Methylprednisolone is reported as an ingredient of Mesol in the following countries:
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Predxal may be available in the countries listed below.
Telmisartan is reported as an ingredient of Predxal in the following countries:
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Patryl may be available in the countries listed below.
Metronidazole is reported as an ingredient of Patryl in the following countries:
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In some countries, this medicine may only be approved for veterinary use.
Rec.INN
N06BC02
0055242-55-2
C15-H22-N4-O3
306
Central stimulant
Vasodilator
1H-Purine-2,6-dione, 3,7-dihydro-3-methyl-1-(5-oxohexyl)-7-propyl-
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Glossary
| BAN | British Approved Name |
| DCF | Dénomination Commune Française |
| IS | Inofficial Synonym |
| JAN | Japanese Accepted Name |
| OS | Official Synonym |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
| USAN | United States Adopted Name |
Azathioprin Sandoz may be available in the countries listed below.
Azathioprine is reported as an ingredient of Azathioprin Sandoz in the following countries:
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Altrénogest may be available in the countries listed below.
Altrénogest (DCF) is also known as Altrenogest (Rec.INN)
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Glossary
| DCF | Dénomination Commune Française |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
Topgesic may be available in the countries listed below.
Mefenamic Acid is reported as an ingredient of Topgesic in the following countries:
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Korylan may be available in the countries listed below.
Codeine phosphate hemihydrate (a derivative of Codeine) is reported as an ingredient of Korylan in the following countries:
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Alipride may be available in the countries listed below.
Cisapride monohydrate (a derivative of Cisapride) is reported as an ingredient of Alipride in the following countries:
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Ambroxol is reported as an ingredient of Mucosurf in the following countries:
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Prednisolon Minims may be available in the countries listed below.
Prednisolone 21-(disodium phosphate) (a derivative of Prednisolone) is reported as an ingredient of Prednisolon Minims in the following countries:
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Paracne may be available in the countries listed below.
Benzoyl Peroxide is reported as an ingredient of Paracne in the following countries:
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Ecasolv may be available in the countries listed below.
Heparin calcium salt (a derivative of Heparin) is reported as an ingredient of Ecasolv in the following countries:
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Lansoprazole-Ratio may be available in the countries listed below.
Lansoprazole is reported as an ingredient of Lansoprazole-Ratio in the following countries:
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In some countries, this medicine may only be approved for veterinary use.
In the US, Fluoxetine (fluoxetine systemic) is a member of the drug class selective serotonin reuptake inhibitors and is used to treat Anxiety and Stress, Body Dysmorphic Disorder, Bulimia, Depression, Dysautonomia, Fibromyalgia, Hot Flashes, Obsessive Compulsive Disorder, Panic Disorder, Postpartum Depression, Premature Ejaculation, Premenstrual Dysphoric Disorder, Schizoaffective Disorder, Trichotillomania and Vulvodynia.
US matches:
UK matches:
Rec.INN
N06AB03
0054910-89-3
C17-H18-F3-N-O
309
Antidepressant: Selective serotonin reuptake inhibitor (SSRI)
Benzenepropanamine, N-methyl-þ-[4-(trifluoromethyl)phenoxy]-, (±)-
International Drug Name Search
Glossary
| BAN | British Approved Name |
| BANM | British Approved Name (Modified) |
| DCF | Dénomination Commune Française |
| IS | Inofficial Synonym |
| OS | Official Synonym |
| PH | Pharmacopoeia Name |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
| SPC | Summary of Product Characteristics (UK) |
| USAN | United States Adopted Name |
